Frequent-Low-Dose Alpha-Lipoic Acid (ALA) Supplements To Take While Chelate Mercury

Do not reproduce without written permission.Part 2 – Supplements For The Cutler ALA Chelation Protocol

As I wrote in Part 1, chelating mercury with ALA burns through vitamins, minerals, and other co-factors as it works to remove mercury from the body and brain. This is why supplementing is necessary when using this protocol.

Understanding and purchasing the supplements has been time-consuming — finding cleaner supplements and ALA in low doses is challenging. However, I believe understanding supplementation is important for health in general for everyone. So I am grateful I had a compelling reason to invest my time and resources into this endeavor.

In this post:

  • Avoiding Excipients, Binders, & Fillers
  • Vitamins & Minerals To Support The AC ALA Chelation Protocol
  • Where To Buy ALA

Avoiding Excipients, Binders, & Fillers

Supplement manufacturers often add excipients (binders, fillers, etc.) to make production quicker / cheaper, coatings to make supplements easier to swallow, or colors to make them look nice. In small doses, they say it is “safe”, but I’m not convinced that taking numerous capsules a day for an extended period of time is okay for my body. This may be a controversial statement, but here is one  example:

“previous research has shown that stearic acid suppresses T cells—your natural killer cells—which are a key component of your immune system. According to that study, stearic acid causes the collapse of cell membrane integrity—an effect that was found to be time and dose dependent—which, ultimately, can destroy cell function.” Dr. Mercola

When I first started this process, part of me wished Cutler had recommended supplements online to make his protocol easier. I read on an archived forum that Cutler suggested using supplements in the citrate form but he no longer shares / endorses brands online. However, even if Cutler had recommend brands I would have probably had to search on my own — I asked Cutler on Facebook about excipients and he did not think they were concerning.

When purchasing supplements, I look for:

  • Physician / high-quality
  • Natural food-based
  • Well-absorbed
  • No additives (like artificial colors)
  • No binders (like hydrogenated soybean oil or gluten)
  • No fillers (like magnesium stearate as a lubricant that may suppress the immune system & titanium dioxide that can lead to problems with the immune function.)
  • No toxins (like GMO corn or heavy metals, GMO gelatin capsules, or Microcrystalline cellulose (MCC)
  • Not grown with genetically modified yeast
  • No common allergens (like wheat, dairy, soy, etc.)
  • Manufactured in the US (not China, however this is usually not an option so at least make sure highest quality of testing and certification are in place.)
  • Not from the local drugstore (quality concerns), Whole Foods (too many excipients), or Amazon (unknown sellers, possible knock-offs)

Vitamins & Minerals To Support ALA Chelation

For dosing supplements, I find serum testing and symptom tracking to be helpful in deciding what my body needs. And to know if what I am taking is absorbing. I also used Fight Autism & Win and AC’s book / AFC yahoo group doses listed below as starting points.

Please note that all humans are unique and react to supplements in different ways. I share my notes on supplements and brand I have tried below, but none of this is advice, an endorsement or recommendation, and all of it is subject to change.

1. Essential Supplements – For simplicity, I initially purchased the Basic Four from Everything Spectrum. One capsule taken four times a day with Vitamin C, E, magnesium and zinc in the forms helpful for chelation. (Note: They are not inexpensive and I still need to research if there are any GMOs, heavy metals, or quality concerns from this company —  the owner made these for her kin, my hope is that they are legit!)

I also purchased these supplements in individual forms:

    • Vitamin C “Buffered” form
    • Dose: 125-200 mg (4x/day, total 500-800 mg) [adult: 1/2 to 2 grams 4x/day].
    • Brand: Now Foods Magnesium Ascorbate. (GMO corn?)
    • Brand: Lypo-Spheric C (Expensive so I take on special occasions, like amalgam removal, traveling, cold/flu. I take half the packet in the am and half in the afternoon. I put a gulp of water in my mouth, tilt my head back, and then squeeze the contents directly into the water in my mouth and swallow. Some like the taste, me not so much. I used to put water in a small cup and put the C in the water but the contents are wasted and stick to the container.)
    • Brand: Calcium Ascorbate Nutribiology (I rotated this in only once in a while as I don’t want to do too much calcium in this form).
    • Brand: May try C-salts (Too much C?) or Magnesium Ascorbate (Has B6 which I cannot take but no corn which is good.)
    • Brand: Plan on adding but must buy through a physician.
    • Notes:
      • AC: “Sodium ascorbate form is good if taking large amount bc it will not make the body acidic like the more common ascorbic acid forms”. On Onibasu Cutler mentioned some are made from beets instead of corn…
      • What does buffered mean…”Mineral salts of ascorbic acid (mineral ascorbates) are less acidic, and therefore, considered “buffered.”” (3)
        • Potassium ascorbate: “The minimal requirement for potassium is thought to be between 1.6 and 2.0 g/day. Fruit and vegetables are rich sources of potassium, and a diet rich in fruit and vegetables may provide as much as 8 to 11 g/day. Acute and potentially fatal potassium toxicity (hyperkalemia) is thought to occur at a daily intake of about 18 g/day of potassium in adults. …The purest form of commercially available potassium ascorbate contains 0.175 grams (175 mg) of potassium per gram of ascorbate.”
        • Magnesium ascorbate: “(RDA) for magnesium is 400-420 mg/day for adult men and 310-320 mg/day for adult women….(UL)…should not exceed 350 mg/day”
    • Vitamin E
    • Dose: 400-800 iu (1 dose or multi) [adult: 1000-3000 IU daily].
    • Brand: Unique E d-alpha tocopherol 400 IU 1333 % (Has glycerin but no soy, if purchasing others look for non-GMO soy). Hurts my chest when I take it orally.
    • Notes: AC: take d-alpha form (NOT dl-alpha form).
    • Magnesium.
    • Dose: 73-150 mg (4x/day, total 300-600 mg) [adult: 500-1000 mg in divided doses]
    • Brand: Pure Encapsulation Magnesium Glycenate 120 mg 30% (PE purchased by Nestle so currently looking for a different brand after 2018)
    • Notes: I take one to three of these every night in addition to the multi-vitamin.
    • AC: Not oxide form. Mercury blocks the body from utilizing magnesium.
    • Zinc
    • 1 mg per pound of wt + 20 mg (1 dose or multi) [adult: 50-100 mg daily]
    • Brand: Metabolic Maintenance Zinc Picolinate 30 mg 200%
    • Notes: When I supplement extra zinc, I take it with evening primrose oil or black currant seed oil (GLA’s) to help with absorption. (See anxiety supplement post for detailed notes). Nausea if taken on empty stomach or wrong form for individual.

2. Optional Supplements – Many of the optional supplements are in the multivitamins I take so I do not supplement them individually: ANRC (this is the brand I use the most), EverythingSpectrum children’s multi-vitamin, and Klaire Labs Vitaspectrum powder (no longer manufactured).

  • Vitamin A
    • Dose: 5,000-10,000 iu / day.
    • Brand: May purchase Rosita Real Foods Norway extra virgin cod liver oil.
    • Notes: Currently not supplementing vitamin A individually.
  • B complex (methylated)
    • Dose: 12-25 mg /day (divided into 3 doses) [adult: equivalent to “b25” or “b50” 4x/day].
    • Brand: Thorne Research Basic B Complex Vegetarian Capsules (has Additives).
    • Brand: Pure Encapsulation B Complex Plus – 120 VegiCaps (has Asc. palmitate).
    • Notes: Currently not taking either. When I did take them, I rotated and split caps into four smaller capsules. I learned the hard way that I have to be careful with some B vitamins even though they are considered water-soluble because it is possible to overdose on them. (Read more on my other supplements here).
  • Calcium
    • Dose: 5-20 mg / lb (divided into 4 doses).
    • Food source: Vegetables and Strauss full fat Greek yogurt sometimes.
    • Notes: Supplementing calcium is controversial so I’m not taking it except a small amount in a multi-vitamin. Prefer food source. Dr. Huggin’s thought calcium does the most damage in excess.
  • Chromium
    • Dose: 100-200 mCg / day or w/every meal if blood sugar issues
    • Brand: Innate Response, 100 mCg (-silica)
    • Notes: I take this ~2/month when I eat something that gives me GI discomfort. May try picolinate form that I can take more often. Chromium can help with sugar levels.
  • Vitamin D3
    • Dose:1000 – 2000 iu / day.
    • Brand: Biotics Research Bio-D-Mulsion Forte Vitamin D — 2000 IU – 1 fl oz as cholecalciferol 1 drop = 1,000 IU 500% (sesame).
    • Brand: Rx Vitamins Physician Formulated Liqui-D3 (evoo base).
    • Brand: Thorne Research Vitamin D3 1000iu / K2 (menatetrenone) 200mcgs per 2 drops
    • Notes: I take this in the morning as it can keep me up at night if I take it too late in the day. I like liquid forms — put it right under the tongue and it absorbs into the body without having to go through the digestive tract. I also try to get in the sun for 20-30 minutes mid-day in non-winter months without sunblock. Sunshine is the best way of getting this “hormone” but I need to supplement on top of that until my tests show otherwise, especially if looking at genes. I’ve heard repeatedly that vitamin D levels should be on the upper range, like 80, for a healing crisis.
  • Vitamin K1 or K2
    • Dose: 500-1000 mCg / day.
    • Brand: Thorne Research K2 liquid 15 drops = 15 mg, 18,750%
    • Notes: I take only 1 drop of this K2 daily with 1 drop of vitamin D in the morning if not taking the combined Thorne version above. Vitamin K helps prevent calcification, especially if supplementing calcium.
  • Molybdenum
    • Dose: 5-20 mCg / lb (divided into 4 doses) [adults: ~1000 mcg/day].
    • Notes: High dose warning if chelating lead. Need to find and take? ALA is sulfury. I am still trying to understand sulphur, sulfate, sulfur

Part of sulphur metabolism produces poisonous sulphites [R-SO3] further down the chain. Sulphites are also found in many foods e.g. white wine. These must quickly be converted to non-toxic sulphates [R-SO4] by the liver. This process uses an enzyme called sulphite oxidase (SO) which requires molybdenum in its core. Often mercury substitutes itself for molybdenum rendering the enzyme useless. This is why molybdenum is one the important minerals to take while chelating, especially those with high copper as molybdenum reduces copper absorption. ALA tends to increase copper retention and molybdenum will help a lot when ALA is being used. (1)

  • Selenium
    • Rec. Dose: 1-2 mcg / lb (divided into 3 doses) [adult: 200 mcg as selenomethionine].
    • Food source: Brazil nuts.
    • Notes: Taking in multi-vitamin. Prefer food source. Started consuming one brazil nut one to a few times a week after testing indicated low-ish. Chew well until paste. I plan to soak and dehydrate them in the future to get rid of anti-nutrients.
    • AC: selenium “binds very tightly to mercury and passivates it so I did not supplement any selenium when I had amalgams and avoided it initially for approx 6 months after.
    • AC:Taking more selenium: 1. Reduces the level of “free” mercury that is bouncing around doing damage. 2. Since mercury binds very tightly to selenium it interferes with the enzyme creation (e.g. glutathione peroxidase and the enzyme which converts the thyroid hormone T4 to the more active form T3.) . Taking more selenium lets the body make more of the enzymes that require selenium.

3. Additional Supplements Based On Bio-Individual Needs

  • Adrenal Support – common for chelation to tax the adrenal glands. Not currently taking any.
  • Antifungals (See Parasite post)
  • Coenzyme Q10 (CoQ10)
    • Dose: Adults: 100-400 mg
    • Notes: NutrEval test showed my body had good amounts without any supplementation. Will re-test when chelating full-time.
  • Essential Fatty Acids
    • Dose: 1-3 TBS / day via fish oil, flax, [1-2 2/3 TBSP = 15-50 g] and borage oil [1-4 g].
    • Brand: Barlean’s flax oil with lignans. Looking for good quality borage oil.
    • Notes: Make sure flax oil is high quality refrigerated / not rancid. Taking first 2 weeks out of monthly cycle. Avoiding fish oil for now (See Anxiety post.) Need to understand EFA breakdown from my NutrEval test – need more DHA and EPA.
  • Herbs – like Swedish Bitters, organic herbs & greens for liver and kidney support.
    • Notes: Need to find a good brand for bitters and also eat more greens and herbs.
  • Milk Thistle
    • Dose: 20-80 mg (3-4 times/day) [250-750 mg silymarin 4x/day pref w/meals].
    • Brand: Pure Encapsulation 250 mg
    • Notes: Supplementing split capsules only on days when chelating.
  • Mixed carotenes, lycopene, etc.:
    • Food source: Organic fruits & vegetables?
    • Notes: Need to research
  • Hydergine
    • Dose: 10-20 mg / day
    • Notes: Need to figure out need?
  • Lithium Orotate
    • Brand: Priority One Vitamins Lithium Organic 5 mg.
    • Notes: Taking in one multivitamin and also when chelating full-time.
    • COMT (+/-) VDR Taq (-/-) individuals will be susceptible to iodine and lithium depletion as they detoxify. No dopamine precursors such as quercetin or herb macuna puriens. Diet low in tyrosine, the amino acid precursor of dopamine. (2)
    • AC: “mercury toxic people need it during chelation, especially when the hair test shows it to be low.”
  • Probiotics
  • Sulphate – Epsom salt baths – make sure sans heavy metals!

4. Supplement I take occasionally:

  • Digestive Enzymes took Integrative Therapeutics Similase on as needed basis. (The company recently added magnesium stearate so switched to a different brand.)
  • Potassium – Currently taking in my multi-vitamin. Potassium is regulated in larger doses and needs a prescription so I get it from food sources like Bieler’s Broth / Potassium Broth.
  • Riboflavin – My B complex that I used to take has vitamin B2 as Ribolfavin 5′-Phosphate Sodium 10 mg 588%. Not supplementing in capsules individually. B2 is hard to find without excipients. I would have supplemented it individually because it tested very low in my body after thallium toxicity.
  • Thiamin – currently getting in a multivitamin (B1 110 mg 7,333%). Tested very low in my body after thallium / arsenic poisoning. Hard to find individually without excipients.
  • Iodine – take food source Dulse when craving it and Kelp supplements. A lot of good info on taking Lugol’s iodine, but I have not had the time yet.
  • Bentonite Clay – binds with mercury but can dehydrate and build up in the gut. I took it on occasion with fiber like organic psyllium husk to help with motility but now just use it for face masks.

5. Supplements I avoid:

  • No Copper (see anxiety posts for more on copper toxicity)
  • No Iron (too much oxidative stress in supplement form, focusing on food forms for now).
  • No Liquid Trace Minerals (contain heavy metals. It is sometimes added to reverse osmosis water. Same with a lot of salt products.)
  • No Amino Acid Supplementation
    • Notes: Genova NutrEval test indicated my body was low in quite a few amino acids. I supplemented once but did not like how it made my head feel. Amino acids like tryptophan, 5HTP GABA help make neurotransmitters, but I think it is complex and try to give my body the food sources to work it out on its own. e.g. GABA is known to cross the blood-brain-barrier and mine is compromised by mercury toxicity.

Sourcing Alpha Lipoic Acid (ALA)

Synthetic ALA, aka thiotic acid, is available OTC, without a prescription in the U.S. However, it is mostly sold in large doses e.g. 100-600 mg capsules.

I was advised to buy the larger capsules and split them as equally as possible by eyesight or buy ALA in bulk powder form (to avoid excipients) and a microscale or micro-scoops, size 4 (smallest) to save money over the long-run.

I purchased measuring tools and a small bag of bulk ALA — ALA looses its potency over time so not good to stock up. But it was too much work to figure out how to use the scale or trust the micro-scoops for my first few ALA rounds. Plus I could only find red micro-scoops sold in 5 packs, blue micro-scoops in a 100 pack and could not find yellow or green ones.

I continued to look and found smaller ALA capsules (5mg, 12mg, and 25mg) made without excipients from a small independent company called EverythingSpectrumA grandmother of an autistic child figured out how to do this! I found it convenient and helpful for the first few rounds of chelation in spite of the price and manufacturing origin.


  • Size / Price: 5 mg 60 caps $13.75, 12 mg 60 caps $14.25, 25 mg 60 caps $14.75.
  • Country origin: China, though high level of testing.
  • Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water) cellulose and l-leucine.
  • Notes: There was no website security so I used PayPal. Also, many supplements are often out of stock.

Two other ALA brands I may try:


  • Size / Price: 300 mg 150 caps $13.99 (250 g powder $32.99)
  • Country origin: US NutraBio FDA registered & inspected facility.
  • Other ingredients: None.


  • Size / Price: 100mg 60 caps from local health food store. (300 mg has fillers).
  • Country origin: ? sent email?
  • Other ingredients: Rice flour (arsenic?). Capsule made of plant cellulose.

ALA options I researched but chose not to purchase:

1. Size / Price: 1 mg, 3 mg, 5 mg, 6.25 mg, 12.5 mg and up. Country origin: Manufactured in a GMP-certified facility using USP-grade raw materials only. Ships from South Africa, takes a few weeks. Other ingredients: 5 mg Microcrystalline cellulose (no MCC!), vegi-caps, all others have MCC, silicon dioxide, magnesium stearate & vegi-caps. This is where I would have to buy DMSA or DMPS that also have these other ingredients.
2. Kirkman Labs Size / Price: 25 mg 90 capsules $18.25 and 50 mg 90 capsules $22.25. However, Additives: Sorbitol, Natural Tropical Punch Flavoring, Alpha Lipoic Acid, Citric Acid, Natural Menthol Flavoring, Silicon Dioxide, Sucralose, Plant Cellulose Caps.
3. – Country origin: China.
4. Pure Encapsulation – Country origin: China.
5. Local Compounding Pharmacy – Resells Pure Encapsulation.

 Be Gutsy!

Healing = Nutrients In + Toxins Out

1. Nutrients In

2. Toxins Out


Supplementation for Social Anxiety Symptoms, Copper Toxicity, And Pyroluria

Do not reproduce without written permission.Part 2: Testing & Supplementation for Anxiety

I am still pretty amazed that supplementing zinc, vitamin B6, and Gamma-linolenic acid can alleviate symptoms of social anxiety for some people.

“Low levels of the mineral zinc and vitamin B6 are frequently associated with a type of anxiety characterized by social anxiety… and bouts of depression.” – Trudy Scott

However, there are a few things I wish I had known before I took a trip down the rabbit hole:

  1. It is possible to overdose on some B vitamins and cause low copper with too much zinc.
  2. Serum testing can be helpful in determining what the body needs.
  3. What is actually causing a lot of anxiety and depression is electromagnetic radiation from the proliferation of the internet of things!

In this post, I share my notes on how I supplemented for mild anxiety. This post is my supplement protocol for mercury poisoning. And if you missed it, Part 1 covers copper toxicity & zinc deficiency, the science of pyroluria, and diagnosing — or rather mis-diagnosing  — pyroluria.

Please note that this is not a comprehensive list of supplements, none of this is a brand endorsement or recommendation, and all of it is subject to change as my body heals.

1. Zinc is an essential trace element that activates several hundred enzymatic reactions fundamental to life and biological activity. (1) A deficiency can increase intestinal permeability.

a. Zinc Tests and Indicators

  • Zinc status test using Designs For Health Liquid Zinc. The zinc tastes terrible right away if zinc levels are sufficient.
  • Genova Essential Fatty Acids Test. Zinc is necessary for the action of an enzyme involved in the fatty acid conversion. So if LA:DGLA is high, there may be a zinc deficiency. (~Yes.)
  • Serum alkaline phosphatase less than 50, or 70, possibly low zinc. (<70.)
  • Serum copper & ceruloplasmin. Serum zinc is not a good indicator.
  • Doctor’s Data Heavy Metal & Essential Elements Hair Test.
  • White spots on nails. (~No)
  • Copper color hair if normally black. (~Yes)

b. Zinc Supplements: Finding the right type of zinc, without copper, for bio-individuality is important. e.g. The wrong form may not be absorbable or cause nausea. Monomethionine or Picolinate may be more easily absorbed for pyroluria.

  • Pure Encapsulation Zinc Citrate.  (~Did not help increase zinc.)
  • Solaray OptiZinc® (as Zinc Monomethionine 30 mg 200% + B6 Pyridoxine HCl, 20 mg 1000%; Additives: magnesium stearate and whole rice concentrate.) Based on Trudy’s recs. (~Worked well, however, I can no longer supplement with it because it also has vitamin B6 – see below).
  • Another Optizinc brand. (~Accidentally purchased, nauseating. Copper?)
  • Metabolic Maintenance Zinc Picolinate 30 mg. (~TBD. Currently using in rotation several times a month and not daily.)
  • Douglas Labs Opti-Zinc 30 mg. (~TBD. Currently using in rotation.)
  • Pure Encapsulation Zinc Picolinate 30 mg. (~TBD. Currently using in rotation.)
  • Zinc is also in my multi-vitamin.

c. Other Notes

  • Zinc taken at the high levels for treating pyroluria can deplete manganese which is necessary for protein metabolism, joint development, and neurotransmitter production. (~Have not supplemented manganese and blood tests do not indicate a need so far.)
  • Food sources: oysters, shellfish such as shrimps and crab, red meat, fish, poultry, and some cheese.
  • Depleters: eating refined sugar, honey, exercise, sweating, and stress. Also many plant sources contain phytic acid which binds to zinc and prevents absorption. And excess copper from vitamins, nut flour, organic farming, IUDs, pots, amalgams, and crowns. Copper is grandfathered into organic farming — a very popular California-made EVOO, sold at stores and farmer’s markets, sprays copper on their crops, as do some avocado growers.

2. Vitamin B-6 plays a critical role in the synthesis of 5 essential neurotransmitters: norepinephrine, serotonin, dopamine, epinephrine, GABA. B-6 deficiency may alter the expression of genes. This may be due to the essential role that B-6 plays in a biochemical pathway referred to as methylation, which greatly affects DNA and RNA activities. (2)

a. B6 Tests

  • Blood work marker gamma-glutamyl transferas (GGTP) may be used to determine the cause of elevated alkaline phosphatase. If less than 10 may need B6. (~Yes.)
  • Organic Acid Test. “elevated levels of xanthurenate in the urine can indicate an insufficiency of vitamin B6, as can elevated levels of kynurenate” (~Wish-list.)
  • Serum blood test. (~Tested out of range from taking too much.)

b. Vitamin B6: Pyridoxine (not methylated) or active form, Pyridoxal 5′-phosphate (100 mg pyridoxine is equivalent to 25 mg P5P). Trudy recommends 100 mg (pyridoxine) and then working up to 500 mg as needed using dream recall. “I often add in P5P 25 mg and may go up to 75 mg or 100 mg and then reduce the B6 – some people seem to do well on a combo on B6 and P5P, some just need B6 and some just need P5P.”

  • Pure Encapsulation Pyridoxal 5′-phosphate 50 mg. (~Split caps in 2-4 portions taking 1 daily for around a month. No longer taking.)
  • Optizinc by Solaray zinc with B6 Pyridoxine HCl 20 mg 1000%. (~No longer taking, see below).
  • Thorne & Pure Encapsulation B complex Pyridoxal 5′-phosphate 10 mg 500%. (~Split caps into 4 portion sizes and took daily for a few months. No longer taking, see below).

c. Other Notes

  • Supplementing B6 in large amounts can deplete magnesium levels. (~I was already magnesium deficient and supplementing).
  • Do not over-supplement vitamin B6 or B3! Too much B6 can give you peripheral neuropathy – tingling symptoms. (~I did not have tingling but my central nervous system felt stressed, had pain in my spine, etc., and a strange skin discoloration on my left hand and left ankle. Tested B6 on my annual blood test and even though I had reduced supplementation a few months back, levels were twice as high as the normal range / HIGH. Read it takes 6 months to clear!?)

We used to think that B vitamins were harmless because, like vitamin C, they’re water soluble and therefore can’t accumulate in the body as can the fat-soluble vitamins (A, D, E, and K). However, we now know that too high an intake of certain of the “B’s” can present problems. For example, vitamin B6 can cause nerve toxicity although it usually doesn’t cause problems in doses lower than 300 mg per day.

“High doses of niacin (vitamin B3) can also cause problems, but you’re not likely to run into trouble unless you’re taking a total of 2000 to 3000 mg per day to lower cholesterol.”

“However, if you’re taking two of the B-50 Complex…the levels of B vitamins you’ll be getting won’t be high enough to cause you trouble, even when combined, as recommended, with a multivitamin and the antioxidant formula. You’ll be getting only an additional 100 mg of B6 and 100 mg of B3.” (3)

According to the National Institutes of Health (NIH), the U.S. Recommended Daily Allowance (RDA) for adult males between 19 and 50 years of age is 1.3 mg, and those over the age of 50 need 1.7 mg. Women between 19 and 50 years of age should take 1.3 mg, and those over 50 should take 1.5 mg. Dr. Weil recommends 50 mg as part of a daily B-complex supplement that contains a full spectrum of B vitamins, including thiamin, B12, riboflavin and niacin. (4)

3. Gamma-linolenic acid (GLA) improves the absorption of zinc. It also helps with “skin conditions like eczema, PMS, and inflammation”.

a. GLA Tests. Those with pyroluria often show low levels of GLA, as well as low DGLA, and adequate levels of EPA and DHA. (~This was true in my case except DHA was also on the low-side. Tested Essential Fatty Acids through my holistic doctor with Genova.)

b. GLA Supplements: Evening Primrose Oil (may be most effective for pyroluria), Black Currant Seed, and Borage Oil. Make sure non-GMO and hexane-free.

  • Pure Encapsulation EPO (~Take it two weeks out of monthly cycle with breakfast with zinc).
  • Pure Encapsulation Black Current Seed Oil (~In the afternoon sometimes).
  • May try BodyBio/E-Lyte or Now Brand Super Primrose.

c. Other Notes

  • EPO may increase estrogen levels. (~Need to research more).
  • Avoid fish oil supplementation. Trudy said that many people with pyroluria need omega-6 fatty acid supplementation and can get omega-3 from food like oily fish, walnuts, green veggies, and grass-fed red meat. “For people with pyroluria who are getting enough omega-3s from food, it’s important not to take them as supplements, because this can worsen symptoms if you aren’t deficient.” (~Yes, stopped taking fish oil because EPA is high on Genova test.)
  • Arachidonic acid from omega-6 deficiency may “lead to the impairment of white blood cell function, primarily the leukocytes which may lead to one being more vulnerable to infection”, neuropathy, skin eruptions, dry skin and hair, slow wound healing, hair loss, kidney dysfunction, etc. (5)

4. Iron is needed to make red blood cells, etc. “HPL also inhibits synthesis of heme explaining why people with pyroluria often also have low levels of iron or ferritin (the body’s storage form of iron and the first indicator of decreased iron levels)”. Trudy

a. Iron Tests – Serum Ferritin. And Iron.

b. Iron Supplements – Controversial to supplement iron. Taken only if low levels, well-tolerated, and helps as identified by monitored testing.

  • Thorne Research Iron Bisglycinate prescribed with vitamin C and taken two weeks out of the month (~Have not taken yet due to ).
  • Floradix is another brand often recommended. (~Tried a sample size once. No nausea but decided not to take for now.)

c. Other Notes

  • Heavy metals can contribute to anemia. They cause oxidative stress as does iron. The body may dump iron stores to try to lower this and protect itself. Chelating and increasing antioxidants, especially vitamin C helps lower oxidative stress and help increase ferritin levels.
  • Per Cutler: Ferritin will come up as soon as you detox them enough that the body doesn’t have to dump iron to protect itself from the mercury. Often iron goes up on its own if you use antioxidants properly. Hair iron does not reflect body stores. The most absorbable iron is the clear red juice from cooking beef roasts. Many people like eating this soaked up into a piece of bread.
  • With the help of my holistic doctor and supplemental digestive enzymes, I have been able to digest pastured red meat and pork again after 20 years!

5. Other Micronutrients

a. Manganese: deficiency may be associated with joint pain, inflammation, and arthritis. It is essential for normal growth, glucose utilization, lipid metabolism, and production of thyroid hormone. (6)

  • Not currently supplementing.

b. Biotin: is essential for healthy brain and nervous system and “is an important factor in the production of energy in the mitochondria.” It may be associated with “depression, lethargy, hearing loss, fungal infections, muscle pain, and abnormal skin sensations such as tingling.” and ” may be evidenced by rashes, dry skin, seborrheic dermatitis, brittle nails, fine or brittle hair, and hair loss.” Biotin is an important factor in the production of energy in the mitochondria. (4)

  • ~Supplemented periodically with methylated B-complexes (see above): 400 mcg, 133%

c. Niacinamide (vitamin B3): necessary for the production of tryptophan, which in turn is necessary for the production of serotonin. Helps to speed pyroluria recovery process. (3)

  • Methylated B-complexes: 130 mg as Niacinamide & 10 mg as Niacin 700%.
  • Supplementing B3 requires a fine balance like B6 or it can be toxic.

d. Pantothenic Acid (vitamin B5): helps weakness and fatigue and re-building adrenal glands that have been exhausted from the tension caused by pyroluria (7)

  • Methylated B-complexes: 110 mg 1,100% as Calcium Panthothenate

e. Avoid gluten?: “pyroluria and gluten sensitivity often co-occur in people with anxiety, depression, autism, alcoholism and other addictions, bipolar disorder” etc.

f.  Avoid histamines?: Pyroluria may occur along with other imbalances like histapenia (low histamine), histadelia (high histamine).

g. Avoid amino acid supplementation: From my brief trial, I am NOT a proponent of taking amino acids to support making neurotransmitters so do not take tryptophan, 5HTP GABA, etc.

6. Vegan / Vegetarian diets often lack iron and other nutrients. Below are some of the nutrients that may be missing if one is not consuming animal protein. The deficiency can impact the body and brain. I worked with my holistic doctor to get my body to be able to digest grass-fed red meat again after being mostly vegetarian for years and share that experience in my upcoming book.

a. Cobalamin (vitamin B12) is the one nutrient that must be supplemented if not eating animal products. (Are lost fingernail orbs a sign of B-12 deficiency because I pretty much only have them on my thumbs?) Since I ate a mostly vegetarian diet for years, at the beginning of my healing crisis I supplemented quite a bit of liquid vitamin B-12 from Pure Encapsulation. It is a red color (not sure why?), had stevia, natural glycerin, sodium benzoate, and citric acid, which I did not like, but I took the trade-off until my blood levels showed improvement. I no longer supplement liquid B12 orally but I B12 is in my multi-vitamin which I take a few times a week in children size doses.

b. Choline – there are high amounts in meat, pork and eggs. So for vegetarians who eat eggs they might not have a deficiency. I was never really a fan and recently learned that I have a slight IgE allergy to eggs. So I usually only eat pastured eggs in cooked dishes and baked goods.

c. Creatine – creatine phosphate helps the mitochondria recycle ATP (energy contributor to body). It is so essential that the body will make it itself if it is not consumed, however producing it in the body uses a lot of methyl groups. Creatine is very important for methylation so this may be one reason I crave red meat more now.

d. Carnitine is important for mitochondria function — it shuttles essential fatty acids in to the mitochondria as fuel and removes them as waste. Red meat and pork are the only food source. Moving the good fat into the brain is important for making neurotransmitters, so without it one can be more depressed, anxious, have poor memory and unmotivated.

Healing Naturally = Nutrients In + Toxins Out

1. Nutrients In

2. Toxins Out

Be Gutsy!